Clot control

Clot control

For neurons, overexcitement is deadly. To avoid this, brain cells must sop up unneeded neurotransmitters from the synapse through membrane-bound transporters. If these transporters fail, neurons and other brain cells get excited to death—a phenomenon that may contribute to brain damage during stroke and Alzheimer's disease. Indeed, brain deterioration after stroke is associated with elevated le...

Clot retraction facilitates clot lysis.

Platelet facilitation of clot lysis was studied using the dilute clot lysis assay, a standardized assay for fibrinolysis shown to correlate with the development of postoperative deep vein thrombosis. Clots prepared from dilute platelet poor plasma showed prolonged clot lysis when compared with clots prepared in a similar fashion from dilute platelet rich plasma. Since in the presence of platele...

Continuous Hands-off Control by CLOT Norm Minimization

In this paper, we consider hands-off control via minimization of the CLOT (Combined L-One and Two) norm. The maximum hands-off control is the L-optimal (or the sparsest) control among all feasible controls that are bounded by a specified value and transfer the state from a given initial state to the origin within a fixed time duration. In general, the maximum hands-off control is a bang-off-ban...

CLOT Norm Minimization for Continuous Hands-off Control

In this paper, we consider hands-off control via minimization of the CLOT (Combined L-One and Two) norm. The maximum hands-off control is the L-optimal (or the sparsest) control among all feasible controls that are bounded by a specified value and transfer the state from a given initial state to the origin within a fixed time duration. In general, the maximum hands-off control is a bang-off-ban...

Clot firmness.